Platform Heart Valve Bioreactor

The base system to test and develop heart valves

 

The Platform Heart Valve Bioreactor provides the base system used to test and develop heart valves under physiological conditions. This system is used for preconditioning valve scaffolds, pre-clinical testing of tissue development, durability, and hemodynamic compatibility, and the testing of cardiovascular implants on heart valves. Using additional accessories, the bioreactor system can be used to replace early stage animal models or in vitro models for studying valve physiology, pathology, and patient-specific theranostics.

Features

  • Simulates pulmonary, aortic, and mitral valve conditions (with additional accessories)

  • Quick and easy assembly

  • Sterile in vitro environment

  • Optically transparent

  • Accommodates bioprosthetic, mechanical, and tissue valves

  • Disposable or autoclavable

  • Real-time data collection

  • Customization available

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Specifications

  • Size (L x W x H): 30 x 13 x 65 cm

  • Media Volume: Less than 1000 mL

  • Stroke Volume: Max of 90 mL

  • Beats per Minute: Max 150 bpm

  • Viscosity: Adjustable

  • Systolic Pressure: Max 200 mmHg

  • Diastolic Pressure: Max 150 mmHg

  • Max Valve Size (D x L): 33 mm x 5 cm

  • Flow Rate: Max 5.5 L/min

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Components

Heart Valve Bioreactor Components
Mechannulus Valve Mount
Mechannulus Valve Mount

The Mechannulus Valve Mount (TM) is a self-adjusting valve holder to allow for simple and efficient mounting. It was specially designed to help grip tissue during assembly, prevent slippage during use, and apply a constant force as the sample shape changes during use. It can be used with bioprosthetic, mechanical, and tissue valves.

Physio Software

Physio Software allows for real time monitoring and data display, giving the user confidence that input conditions are being achieved by the system. Data can be collected continuously or at user-specified intervals and is automatically exported as CSV files for easy use. The optically transparent system allows for clear visualization and monitoring of the functional valve. The software is capable of monitoring the following data: heart rate, cycle count, total flow, averaged stroke volume, cusp movement, and systolic & diastolic pressure in the aorta and ventricle.

Control Box
Control Box

The control boxes are designed to control anywhere from one to four bioreactors at a time. The control boxes maintain airflow in and out of the systems and regulate flow and pressure.

Quick Connect Fittings
Quick Connect Fittings

Unlike traditional fittings, our Quick Connect Fittings are a single-piece, quick-action fitting that installs with a simple push. In addition, the lack of threading eliminates the need for traditional tape sealing methods. Its innovative design will help users save time and money, reduce complications, and provide an easier way to obtain a cleaner and more reliable seal. The fittings are available in many sizes, materials, and connection types making them suitable for a variety of applications.

aCCESSORIES

Heart Valve Bioreactor Accessories
Aortic Conditions Module
Aortic Conditions Module

The Aortic Conditions Module adds additional chambers to the Platform Heart Valve Bioreactor to test conditions specific to the aortic valve. This module allows the user to independently control systolic pressure, diastolic pressure, and flow rate for all normal and pathological conditions.

Pulmonic Conditions Module
Pulmonic Conditions Module

The Pulmonic Conditions Module utilizes a hydrostatic pressure head to create the conditions specific to the pulmonary heart valve by adding additional chambers to the Platform Heart Valve Bioreactor.

Rotating Cell Seeder
Rotating Cell Seeder

The Rotating Cell Seeder is to be used in the development of novel tissue engineered heart valves by allowing for patient-specific cell seeding to heart valve roots. The device provides control over rotation style and speed, is autoclavable for repeated use, and provides a sterile in vitro environement. When partnered with our Platform Heart Valve Bioreactor you can now fully develop and test your patient-specific heart valve.